With the deepening understanding of the pathogenesis of retinopathy of prematurity (ROP) and the continuous development of new drugs, intravitreal injection of anti-vascular endothelial growth factor (VEGF) drugs has gradually become an important treatment of ROP. Therefore, it is of great significance to standardize the operation of ROP intravitreal injection in order to make sure that infants receive safe and effective treatment. Based on the actual situation of the diagnosis and treatment of ROP in China, and after careful, comprehensive and full discussion on the indications and contraindications, injection requirements, operation precautions and post-treatment precautions of intravitreal injection of anti-VEGF drugs in the treatment of ROP, Pediatric Retinology Group of Ophthalmology Professional Committee of Cross-Strait Medical and Health Exchange Association form an expert consensus, and it is reviewed and modified by Fundus Disease Group of Chinese Medical Association Ophthalmology Branch for ophthalmologists' reference in clinical work.